Cerebrospinal fluid aquaporin‐4‐immunoglobulin G disrupts blood brain barrier

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Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier

To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice, and the distribution and pathogenic impact was evaluated. A distinct distribution pattern of aquaporin-4-immunoglobulin G deposition was observed in...

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ژورنال

عنوان ژورنال: Annals of Clinical and Translational Neurology

سال: 2015

ISSN: 2328-9503,2328-9503

DOI: 10.1002/acn3.221